Posts Tagged ‘Pere Gascón’

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Monday June 17th, 2013

A population of cells which decreases after pregnancy is related to breast cancer risk

Epidemiological and experimental data suggest that full-term pregnancy (lasting 37 – 40 weeks) at an early age reduces the risk of developing breast cancer in postmenopausal women. However, the mechanism responsible for this protection is unknown. A study led by researchers at the Dana Farber Cancer Institute of the Harvard Medical School (Boston, USA), in collaboration with the Johns Hopkins University School of Medicine (Baltimore, USA), identifies molecular differences in breast cells from women with and without children. The work was published in the journal Cell Stem Cell from the Cell group, with Dr. Vanessa Almendro as its co-first author. Shes is a member of the IDIBAPS Molecular and Translational Oncology team directed by Dr. Pere Gascon, Chief of Oncology at the Hospital Clínic of Barcelona. The results of the investigation suggest that CD44+ p27+ cells are potential progenitors of estrogen receptor-positive (ER+) postmenopausal breast cancer, the most common form of the disease.

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Thursday June 13th, 2013

Students from the Bàrkeno School support cancer research with a check obtained by collecting 700 kg of bottle caps

Bàrkeno School of Barcelona is a center for Early Childhood and Primary Education located in the Marina district of the Zona Franca. On Wednesday June 12 the school invited Dr. Pere Gascon, Chief of Oncology at Hospital Clínic of Barcelona and head of the IDIBAPS team Molecular and Translational Oncology, to a very special event: The delivery of a 220 Euros check that students from the school, between 3 and 12 years, had earned by collecting thousands of bottle caps.

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Monday January 14th, 2013

Institutional video presentation of the CELLEX Biomedical Research Centre


This is the corporate video that was projected during the presentation of the CELLEX Biomedical Research Centre, which took place on January 10th. With the video IDIBAPS wants to summarize the diversity and potential of the research that will develop the 23 research teams working in the new facilities.

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Thursday May 21st, 2009

Oxaliplatin Promotes the Survival of Drug-Resistant Colon Tumor Cells

Dr. Elisabet Ametller and Dr. Vanessa Almendro at Hospital Clínic

Oxaliplatin is a drug that is widely used to treat colon cancer, but its efficacy is limited by the development of resistance to chemotherapy of the tumor cells. The chemoresistant cells undergo molecular changes that protect them from the cell death induced by the drugs, thus re-establishing the processes of tumor progression. An article published in PLoS One analyzes the role of the metalloproteinase, MMP7, in the resistance mechanisms of these cells and its effect on the Fas receptor involved in promoting cell death by apoptosis. This study was directed by Dr. Vanessa Almendro of the department of medical oncology at Hospital Clínic-IDIBAPS and by Dr. Pere Gascón, and involved the collaboration of Dr. Elisabet Ametller, among others. The results show that, in colon cancer cell lines, MMP7 is directly related to the acquisition of resistance to oxaliplatin and its inhibition re-establishes sensitivity to the drug due to an increase in the Fas receptor. Furthermore, the authors observed that, surprisingly, the Fas receptor undergoes changes in functionality in cells resistant to oxaliplatin, leading it to induce survival signals instead of apoptotic signals.
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