Posts Tagged ‘Pau Serra’


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Friday March 01st, 2013

Major histocompatibility complex molecules regulate autoimmune diabetes through dendritic cells

The major histocompatibility complex (MHC) comprises a group of cell surface molecules that mediate interactions between immune cells. They determine, for example, the compatibility of donors and hosts for organ transplants. Genetically-encoded variation in MHC class II molecules has long been known to provide risk or afford resistance to multiple autoimmune diseases, including type 1 diabetes, albeit through very poorly understood mechanisms.

A work published in the American journal Proceedings of the National Academy of Sciences (PNAS) shows that anti-diabetogenic MHC class II molecules operate by promoting the differentiation of disease-promoting white blood cells into disease-suppressing ones. This research was led by Professor Pere Santamaria from the University of Calgary and ISIS scientist of IDIBAPS, in collaboration with Dr. Pau Serra, an IDIBAPS’ Ramón y Cajal investigator.

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