Posts Tagged ‘oncologia mèdica’

Tuesday January 23rd, 2018

Researchers identify a protein that keeps metastatic breast cancer cells dormant

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body). A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light on the molecular basis underlying how the expression of certain genes facilitates the spread of metastatic lesions. Dr. Aleix Prat, Head of the Clinical Oncology Department at Hospital Clínic and of the Translational genomics and targeted therapeutics in solid tumors research team at IDIBAPS, has participated in this study. Read the rest of this entry »

Comments Closed
Thursday April 20th, 2017

A study reveals the biological changes in breast cancer between the primary tumor and metastases

A study published in the journal Cancer Research underscores the importance of the molecular characterization of the metastases in breast cancer. Researchers have described, for the first time, that the longer the time from the onset of the tumor to the development of metastasis is, the more aggressive this cancer becomes. They have also shown that between the initial tumor and the metastasis the subtype of breast cancer can change in up to 40% of cases. The work has been coordinated by Aleix Prat, Head of the Oncology Department of the Hospital Clínic, Head of the Translational Genomics team and directed therapies in solid tumors IDIBAPS team and Head of the VHIO Translational Genomics Group. The first author of the study is Juan Miguel Cejalvo, PhD student of the PhD4MD program in the group led by Aleix Prat at IDIBAPS and in the Growth Control and Cancer Metastasis group of the Institute for Research in Biomedicine (IRB Barcelona), led by the ICREA researcher Roger Gomis.

Read the rest of this entry »

Comments Closed
Tuesday July 19th, 2016

Hospital Clínic makes a commitment to the molecular diagnostic of solid tumors in clinical practice

Hospital Clínic de Barcelona goes one step forward in the molecular diagnosis of solid tumors with a single test that detects multiple mutations within 22 genes in patients with advanced lung cancer, melanoma and colorectal cancer. The implementation of this genetic test based on massive parallel sequencing technologies allows shortening the time of diagnosis and personalizing the treatment for each patient. With this test, the Medical Oncology department at Hospital Clínic, together with the Biomedical Diagnostic Center (CDB), positions at the forefront of the clinical application of this diagnostic tool in the Spanish public health system, because of the technology used and the number of genes and tumors analyzed.

Read the rest of this entry »

Comments Closed