Posts Tagged ‘leucèmia limfàtica crònica’

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Tuesday October 23rd, 2018

Researchers from IDIBAPS and CRG, awarded with an ERC Synergy grant to unravel chronic lymphocytic leukemia

The European Research Council (ERC) today announced the results of the 2018 Synergy Grants call for proposals. The aim of Synergy Grants is to address ambitious research questions that can only be answered by the coordinated work of a small group of two to four principal investigators and their teams, bringing together their complementary skills, knowledge and resources. The ultimate goal of the scheme is to give support to a close collaborative interaction that will enable transformative research at the forefront of science, capable of yielding groundbreaking or even unpredictable scientific results and/or cross-fertilizing disciplines. Read the rest of this entry »

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Tuesday May 22nd, 2018

IDIBAPS researchers decipher how leukaemia’s genome works

A team of researchers from IDIBAPS show for the first time the complete epigenome of chronic lymphocytic leukaemia, the most common type of leukaemia. The study, published in Nature Medicine, provides a high-resolution map of the functions of the genome, which steps forward into cancer molecular research. The comparison of the map for this type of leukaemia with the map of healthy cells shows hundreds of regions that change their functionality in leukaemia which help to understand the illness better and represent potential targets for the development and application of new therapies. Read the rest of this entry »

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Thursday September 17th, 2015

Developed a DNA chip to better detect and lead the treatment of chronic lymphocytic leukemia

Researchers from the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and the Hospital Clínic of Barcelona, in collaboration with qGenomics, have developed a DNA chip, or array, to analyze the genome and identify genetic abnormalities in chronic lymphocytic leukemia. This chip allows overcoming the limitations for the detection of changes of the current techniques, such as fluorescent in situ hybridization (FISH), and can be used for a more accurate diagnosis of the disease.

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Wednesday July 22nd, 2015

Mutations in the dark side of the genome cause leukemia

A study, published today in the journal Nature, marks a milestone in the understanding of chronic lymphocytic leukemia, the most common leukemia in adults, as the genomes of normal and tumor cells for more than 500 patients have been sequenced providing novel mechanisms involved in the development of this tumor. Cancer originates due to the progressive accumulation of mutations in the genome of normal cells. This is why seven years ago the International Cancer Genome Consortium (ICGC) was established. The main aim of this consortium was to sequence the genome of tumor cells from at least 500 patients, and do it for each of the 50 most frequent types of cancer in the world. The Spanish-led consortium in charge of the chronic lymphocytic leukemia study has been the first team to accomplish this ambitious objective. In this work, led by Dr. Carlos Lopez-Otin, from the University of Oviedo and by Dr. Elias Campo, from Hospital Clinic, IDIBAPS and University of Barcelona, more than 60 researchers from different centers have collaborated to mine the three billion bases of each tumor genome in search of alterations responsible for the development of this disease.

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Friday June 12th, 2015

Dr. Elías Campo recieves the Eugenio Rodriguez Pascual Award for his contributions to diagnosis and cancer therapy

Dr. Elias Campo, Research Director of the Hospital Clinic of Barcelona, Head of the Human and experimental functional oncomorphology IDIBAPS team and full professor of anatomical pathology at the University of Barcelona (UB), has been recieved the Eugenio Rodriguez Pascual Award for his contributions to diagnosis and cancer therapy. In particular, for his research about mantle cell lymphoma and laryngeal cancer. The award was presented by the Minister of Health, Social Services and Equality, Alfonso Alonso, in a ceremony held last June 10th at the Casino de Madrid.

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Monday October 27th, 2014

New computational method allows the identification of genetic alterations in cancer patients within hours

IDIBAPS and Hospital Clínic have participated in the development of a new computational method that enables to detect genetic changes responsible for the onset and progression of tumors in a simple, quick and precise way. The research is published in the latest issue of the prestigious journal Nature Biotechnology. This methodology, called SMUFIN (Somatic Mutations Finder), is capable of analyzing the complete genome of a tumor and identifying its mutations in a few hours. In addition, it is able to identify alterations which had previously not been revealed, even using methods which require the use of supercomputers over several weeks.

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