Posts Tagged ‘Jorge Ferrer’

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Tuesday February 07th, 2017

Scientists discover that non-coding RNA regulates the expression of key genes in diabetes

Researchers at IDIBAPS and the Imperial College London publish a study in which they have discovered that RNA sequences that do not encode for proteins play a key role in the expression of certain genes in the beta cells of the pancreas. These genes are known to be involved in the development of different forms of diabetes. Dr. Jorge Ferrer, head of the team Genomic Programming of Beta Cells and Diabetes at IDIBAPS and at the Imperial College London and researcher at the Networked Biomedical Research Center for Diabetes and Associetaed Metabolic Diseases (CIBERDEM), coordinates this study published in the journal Cell Metabolism. Read the rest of this entry »

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Tuesday April 28th, 2015

Discovered the genome regions responsible for pancreas formation

A group of researchers from IDIBAPS and the Imperial College London have developed, for the first time, a collection of the genome regions that contain the instructions for the pancreas development in the human embryo. There are included both the genes and those regions of the genome, called enhancers, that act as a kind of switches and play a key role in the genes activation or deactivation. The analysis of these switches has revealed a new mechanism that promotes the formation of the pancreas. In the article, published in the journal Nature Cell Biology, a model of stem cells differentiated to pancreatic progenitor cells, has also been validated which will facilitate the study of this organ in vitro from now on. Dr. Jorge Ferrer, head of the Genomic Programming of Beta Cells and Diabetes team at IDIBAPS and the Imperial College London, coordinates this study in which has also participated Dr. Meritxell Rovira, researcher in the same group at IDIBAPS.

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Friday July 18th, 2014

IDIBAPS is the Spanish entity with more activities funded by the Innovative Medicines Initiative

The report named “Spanish Participation in the Innovative Medicines Initiative (IMI)” has been recently published by the Center for Industrial Technological Development (CDTI). This report lists the main indicators of participation in 8 of the 11 IMI’s calls supported under the 7th Framework Programme.

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Monday January 13th, 2014

Non-coding DNA implicated in type 2 diabetes

Variations in non-coding sections of the genome might be important contributors to type 2 diabetes risk, according to a new study. DNA sequences that don’t encode proteins were once dismissed as “junk DNA”, but scientists are increasingly discovering that some regions are important for controlling which genes are switched on. The new study, published in Nature Genetics, is one of the first to show how such regions, called regulatory elements, can influence people’s risk of disease. The present work is a collaborative effort with three first authors: Lorenzo Pasquali (IDIBAPS-CIBERDEM), Kyle J Gaulton (University of Oxford), Santiago A Rodríguez-Seguí (former IDIBAPS researcher and now at Universidad de Buenos Aires), with Dr. Jorge Ferrer (IDIBAPS_CIBERDEM-Imperial College London) as its last author. The present work, led by IDIBAPS’ investigators, was supported by the CIBER of Diabetes and Metabolic Diseases (CIBERDEM) and investigators from CSIC.

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Monday November 11th, 2013

Cause of genetic disorder found in “dark matter” of DNA

For the first time, scientists have used new technology which analyses the whole genome to find the cause of a genetic disease in what has previously referred to as “junk DNA”. Pancreatic agenesis results in babies being born without a pancreas, leaving them with a lifetime of diabetes and problems digesting food. In a breakthrough for genetic research published by Nature Genetics, teams led by the University of Exeter Medical School and IDIBAPS – Imperial College London found that the condition is most commonly caused by mutations in a newly identified gene regulatory element in a remote part of the genome, which can now be explored thanks to advances in genetic sequencing. The first co-signers are Dr. Michael N. Weedon, from the University of Exeter, and Inês Cebola, from IDIBAPS and the Imperial College of London, while the co-directors of the study are Dr. Jorge Ferrer, head of the IDIBAPS Genomic Programming of Beta Cells and Diabetes, currently Chair in Genetics and Medicine at Imperial College London, and Dr. Andrew T. Hattersley, from the University of Exeter. The study has received, among others, support from the CIBER of Diabetes and Metabolic Diseases (CIBERdem).

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Thursday October 03rd, 2013

Experts in beta cells meet in Sitges to discuss new strategies for diabetes

After the 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), which brought 20,000 diabetologists to Barcelona until September 27th, a more specific symposium was held in Sitges on recent advances in the field of pancreatic beta cells regenerative medicine and gene regulation. The symposium coordinators were Dr. Eduard Montanya, from IDIBELL-UB, and Dr. Jorge Ferrer, from IDIBAPS – Imperial College London.

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