Posts Tagged ‘Jaume Bosch’

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Monday July 30th, 2018

Statins efficacy confirmed in advanced phases of cirrhosis in an animal model

Researchers from IDIBAPS publish a translational paper in Gastroenterology demonstrating that statins improve survival and main clinical symptoms in advanced cirrhosis and acute-on-chronic liver failure (ACLF). The paper also describes and validates the first animal model of ACLF, which has allowed studying the beneficial effects of statins. The work has been coordinated by Jordi Gracia-Sancho, leader of the Liver Vascular Biology Research Group from IDIBAPS and CIBEREHD, and Jaume Bosch, emeritus investigator from the same group, and first authors are Dinesh Tripathi and Marina Vilaseca. Read the rest of this entry »

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Thursday November 24th, 2016

Simvastatin can lengthen the survival of patients with cirrhosis

Gastroenterology has published a clinical trial promoted and coordinated by Hospital Clínic – IDIBAPS where it is shown that the addition of simvastatin to standard therapy in patients with cirrhosis can lengthen their survival. The article is signed by, among others, Dr. Jaume Bosch, hepatologist at Clínic and head of the research team Liver hemodynamics and portal hypertension of IDIBAPS; Dr. Juan Carlos García-Pagán and Juan González-Abraldes, from the same research group, and Dr. Fernando Torres, director of the IDIBAPS medical statistics platform. Read the rest of this entry »

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Friday December 11th, 2015

Scientists in Barcelona discover a potential treatment for cirrhosis

Scientists headed by Raúl Méndez, ICREA research professor at the Institute for Research in Biomedicine (IRB Barcelona), and Mercedes Fernández, at IDIBAPS in Barcelona, reveal that the inhibition of CPEB4 protein may prevent the development of the abnormal blood vessels associated with cirrhosis. Pathological angiogenesis is one of the most serious complications in patients with cirrhosis and a key factor in the development and worsening of the disease. Consequently, many research efforts focus on identifying treatments for this condition. The results of the study have been published in the most recent issue of Gastroenterology.

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Tuesday June 30th, 2015

Researchers from IDIBAPS and Hospital Clínic awarded for the best communication on basic Gastroenterology at the SEPD Congress

A study conducted by researchers from IDIBAPS and Hospital Clinic of Barcelona has received the Arias Vallejo prize for the best communication in Basic Gastroenterology presented at the LXXIV Annual Congress of the Spanish Society of Digestive Pathology (SEPD). This prize is awarded by the Digestive System Spanish Foundation (FEAD). Sergi Guixé-Muntet and Dr. Jordi Gracia-Sancho, researchers at the Liver hemodynamics and portal hypertension IDIBAPS team, are the first and last authors, respectively. Doctors Sergi Vila, Carmen Peralta, Juan Carlos Garcia-Pagan and Jaume Bosch have also participated in the study entitled “Role of autophagy in endothelial hepatic ischemia and reperfusion”.

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Monday January 12th, 2015

The induction of the transcription factor KLF2 improves liver cirrhosis and portal hypertension

A study led by researchers from IDIBAPS shows, for the first time, that the induction in the liver of the transcription factor called KLF2 (Kruppel-like factor 2), a protein that promotes the expression of vasoprotective genes, significantly improves liver cirrhosis and portal hypertension. Dr. Jordi Gracia-Sancho, Ramón y Cajal researcher at the IDIBAPS group Liver hemodynamics and portal hypertension: Digestive bleeding secondary to ruptured esophageal varicose veins, and Dr. Jaume Bosch, director of the same team, have led this study published in the Gut journal whose first authorship share Giusi Marrone and Raquel Maeso-Díaz. This research was conducted in collaboration with a team from the Harvard Medical School & Brigham and Women’s Hospital.

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Thursday July 18th, 2013

Two IDIBAPS works among the Gastroenterology most cited articles between 2009-2012

Gastroenterology is the premiere journal in the field of gastroenterology and hepatology. It recently published a ranking of the top 10 most cited articles by Scopus for 2009-2012. Among the list of the most influential works published in Gastroenterology in recent years you will find two original papers led by investigators from the IDIBAPS teams Liver hemodynamics and portal hypertension, directed by Dr. Jaume Bosch, and Gastrointestinal and pancreatic oncology, directed by Dr. Antoni Castells.

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