Posts Tagged ‘genómica’

Tuesday July 19th, 2016

Hospital Clínic makes a commitment to the molecular diagnostic of solid tumors in clinical practice

Hospital Clínic de Barcelona goes one step forward in the molecular diagnosis of solid tumors with a single test that detects multiple mutations within 22 genes in patients with advanced lung cancer, melanoma and colorectal cancer. The implementation of this genetic test based on massive parallel sequencing technologies allows shortening the time of diagnosis and personalizing the treatment for each patient. With this test, the Medical Oncology department at Hospital Clínic, together with the Biomedical Diagnostic Center (CDB), positions at the forefront of the clinical application of this diagnostic tool in the Spanish public health system, because of the technology used and the number of genes and tumors analyzed.

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Tuesday January 12th, 2016

A genetic test at the time of diagnosis, useful for predicting treatment response in breast cancer

Researchers at Hospital Clínic and IDIBAPS lead a study in which a genomic test performed at the time of diagnosis in breast cancer is useful to identify the real tumor subtype and provide valuable information regarding prognosis and the tumor response to chemotherapy. When transferred to the clinical practice, allows deciding within a multidisciplinary committee the best treatment and follow-up strategy in each case. The article has been published in the journal BMC Medicine and has been coordinated by Dr. Aleix Prat, head of the Onclology (oncology) Department at Hospital Clínic and the Translational genomics and targeted therapeutics in solid tumors IDIBAPS team. Researchers at the Vall d’Hebron Institute of Oncology (VHIO) and the University of North Carolina have also participated.

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Monday November 11th, 2013

Cause of genetic disorder found in “dark matter” of DNA

For the first time, scientists have used new technology which analyses the whole genome to find the cause of a genetic disease in what has previously referred to as “junk DNA”. Pancreatic agenesis results in babies being born without a pancreas, leaving them with a lifetime of diabetes and problems digesting food. In a breakthrough for genetic research published by Nature Genetics, teams led by the University of Exeter Medical School and IDIBAPS – Imperial College London found that the condition is most commonly caused by mutations in a newly identified gene regulatory element in a remote part of the genome, which can now be explored thanks to advances in genetic sequencing. The first co-signers are Dr. Michael N. Weedon, from the University of Exeter, and Inês Cebola, from IDIBAPS and the Imperial College of London, while the co-directors of the study are Dr. Jorge Ferrer, head of the IDIBAPS Genomic Programming of Beta Cells and Diabetes, currently Chair in Genetics and Medicine at Imperial College London, and Dr. Andrew T. Hattersley, from the University of Exeter. The study has received, among others, support from the CIBER of Diabetes and Metabolic Diseases (CIBERdem).

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