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Monday July 30th, 2018

Statins efficacy confirmed in advanced phases of cirrhosis in an animal model

Researchers from IDIBAPS publish a translational paper in Gastroenterology demonstrating that statins improve survival and main clinical symptoms in advanced cirrhosis and acute-on-chronic liver failure (ACLF). The paper also describes and validates the first animal model of ACLF, which has allowed studying the beneficial effects of statins. The work has been coordinated by Jordi Gracia-Sancho, leader of the Liver Vascular Biology Research Group from IDIBAPS and CIBEREHD, and Jaume Bosch, emeritus investigator from the same group, and first authors are Dinesh Tripathi and Marina Vilaseca. Read the rest of this entry »

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Monday January 12th, 2015

The induction of the transcription factor KLF2 improves liver cirrhosis and portal hypertension

A study led by researchers from IDIBAPS shows, for the first time, that the induction in the liver of the transcription factor called KLF2 (Kruppel-like factor 2), a protein that promotes the expression of vasoprotective genes, significantly improves liver cirrhosis and portal hypertension. Dr. Jordi Gracia-Sancho, Ramón y Cajal researcher at the IDIBAPS group Liver hemodynamics and portal hypertension: Digestive bleeding secondary to ruptured esophageal varicose veins, and Dr. Jaume Bosch, director of the same team, have led this study published in the Gut journal whose first authorship share Giusi Marrone and Raquel Maeso-Díaz. This research was conducted in collaboration with a team from the Harvard Medical School & Brigham and Women’s Hospital.

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