A study published in the journal Cancer Cell deciphers for the first time the epigenome of mantle cell lymphoma, an aggressive type of cancer derived from B lymphocytes, the cells of the immune system responsible for producing antibodies. The research reveals in detail the epigenetic history of lymphoma. On the one hand, it identifies the cell of origin and, on the other, it reveals that the more the epigenome of tumor cells evolves, the more aggressive the patient’s clinical course is. In addition, researchers discover that three-dimensional DNA conformation changes in lymphomas and leads to the activation of cancer genes. Dr. Iñaki Martín-Subero has coordinated the study. He is researcher at the University of Barcelona and at the Molecular Mechanisms of Lymphoid Neoplasms IDIBAPS research group, led by Dr. Elías Campo.
Posts Tagged ‘Elias Campo’
Clinic-IDIBAPS researchers identify that the epigenetic history of lymphoma predicts its clinical course
Andreu Mas-Colell encourages researchers from IDIBAPS to apply for a grant from the European Research Council
Professor at the University Pompeu Fabra (UPF), Andreu Mas-Colell, encourages researchers from IDIBAPS to “apply for an European Research Council (ERC) grant given the high scientific level in this institution”. Professor Mas-Colell made these remarks during the inaugural conference of the celebrations of the 20th anniversary of IDIBAPS on Monday 30th May.
Dr. Elías Campo, Research Director at Hospital Clínic, head of the Human and experimental functional oncomorphology team at IDIBAPS and Chair at the Faculty of Medicine and Health Sciences of the University of Barcelona (UB), has been awarded with the “Rey Jaime I” award in the “medical research” category. Last Tuesday the list of winners of the 2016 edition of the awards was announced in an official ceremony held at the Palace of the Generalitat Valenciana, with the presence of the board chairman, Ximo Puig; the president of the Valencian Foundation for Advanced Studies and Vice President of the Rey Jaime I” Awards Foundation, Vicente Boluda, and the Permanent Secretary of the “Rey Jaime I” Awards, Santiago Grisolía.
A study, published today in the journal Nature, marks a milestone in the understanding of chronic lymphocytic leukemia, the most common leukemia in adults, as the genomes of normal and tumor cells for more than 500 patients have been sequenced providing novel mechanisms involved in the development of this tumor. Cancer originates due to the progressive accumulation of mutations in the genome of normal cells. This is why seven years ago the International Cancer Genome Consortium (ICGC) was established. The main aim of this consortium was to sequence the genome of tumor cells from at least 500 patients, and do it for each of the 50 most frequent types of cancer in the world. The Spanish-led consortium in charge of the chronic lymphocytic leukemia study has been the first team to accomplish this ambitious objective. In this work, led by Dr. Carlos Lopez-Otin, from the University of Oviedo and by Dr. Elias Campo, from Hospital Clinic, IDIBAPS and University of Barcelona, more than 60 researchers from different centers have collaborated to mine the three billion bases of each tumor genome in search of alterations responsible for the development of this disease.
Dr. Elías Campo recieves the Eugenio Rodriguez Pascual Award for his contributions to diagnosis and cancer therapy
Dr. Elias Campo, Research Director of the Hospital Clinic of Barcelona, Head of the Human and experimental functional oncomorphology IDIBAPS team and full professor of anatomical pathology at the University of Barcelona (UB), has been recieved the Eugenio Rodriguez Pascual Award for his contributions to diagnosis and cancer therapy. In particular, for his research about mantle cell lymphoma and laryngeal cancer. The award was presented by the Minister of Health, Social Services and Equality, Alfonso Alonso, in a ceremony held last June 10th at the Casino de Madrid.
Researchers from IDIBAPS and the University of Barcelona (UB) lead a study, published today in the prestigious journal Nature Genetics, which reveals an unexpected connection between epigenetic changes associated with lymphocytes’ maturation and those observed in cancer. Both processes share similar changes in large regions of the genome. The work, led by Dr. Iñaki Martín-Subero, researcher in the Pathology, Pharmacology and Microbiology Department at UB and IDIBAPS, is the first in analyze the epigenome during cell maturation of B lymphocytes, the immune system cells responsible of the antibodies production, and provides epigenetic maps of each step in this process.