A study, published today in the journal Nature, marks a milestone in the understanding of chronic lymphocytic leukemia, the most common leukemia in adults, as the genomes of normal and tumor cells for more than 500 patients have been sequenced providing novel mechanisms involved in the development of this tumor. Cancer originates due to the progressive accumulation of mutations in the genome of normal cells. This is why seven years ago the International Cancer Genome Consortium (ICGC) was established. The main aim of this consortium was to sequence the genome of tumor cells from at least 500 patients, and do it for each of the 50 most frequent types of cancer in the world. The Spanish-led consortium in charge of the chronic lymphocytic leukemia study has been the first team to accomplish this ambitious objective. In this work, led by Dr. Carlos Lopez-Otin, from the University of Oviedo and by Dr. Elias Campo, from Hospital Clinic, IDIBAPS and University of Barcelona, more than 60 researchers from different centers have collaborated to mine the three billion bases of each tumor genome in search of alterations responsible for the development of this disease.
Posts Tagged ‘Elias Campo’
Dr. Elías Campo recieves the Eugenio Rodriguez Pascual Award for his contributions to diagnosis and cancer therapy
Dr. Elias Campo, Research Director of the Hospital Clinic of Barcelona, Head of the Human and experimental functional oncomorphology IDIBAPS team and full professor of anatomical pathology at the University of Barcelona (UB), has been recieved the Eugenio Rodriguez Pascual Award for his contributions to diagnosis and cancer therapy. In particular, for his research about mantle cell lymphoma and laryngeal cancer. The award was presented by the Minister of Health, Social Services and Equality, Alfonso Alonso, in a ceremony held last June 10th at the Casino de Madrid.
Researchers from IDIBAPS and the University of Barcelona (UB) lead a study, published today in the prestigious journal Nature Genetics, which reveals an unexpected connection between epigenetic changes associated with lymphocytes’ maturation and those observed in cancer. Both processes share similar changes in large regions of the genome. The work, led by Dr. Iñaki Martín-Subero, researcher in the Pathology, Pharmacology and Microbiology Department at UB and IDIBAPS, is the first in analyze the epigenome during cell maturation of B lymphocytes, the immune system cells responsible of the antibodies production, and provides epigenetic maps of each step in this process.
The Lilly Foundation has awarded the 2015 Biomedical Research Awards in the categories of preclinical and clinical research, respectively, to Dr. Miguel Beato, researcher, founder and first director of the Centre for Genomic Regultaion (CRG), and Dr. Elías Campo, Research Director of Hospital Clínic and Fundació Clínic and head of the Human and Experimental Functional Oncomorphology IDIBAPS Group. These awards recognize excellence scientific career of researchers who have contributed to a high quality Biomedical research in Spain.
New computational method allows the identification of genetic alterations in cancer patients within hours
IDIBAPS and Hospital Clínic have participated in the development of a new computational method that enables to detect genetic changes responsible for the onset and progression of tumors in a simple, quick and precise way. The research is published in the latest issue of the prestigious journal Nature Biotechnology. This methodology, called SMUFIN (Somatic Mutations Finder), is capable of analyzing the complete genome of a tumor and identifying its mutations in a few hours. In addition, it is able to identify alterations which had previously not been revealed, even using methods which require the use of supercomputers over several weeks.
Thomson Reuters has published the list of the Highly Cited Researchers, a compilation of the most influential names in science. 50 Spanish researchers from different broad fields of sciences and social sciences appear on the list. In the field of Clinical Medicine, four of the seven Spanish investigators listed are researchers from IDIBAPS. The health research institute associated to Hospital Clínic and Universitat de Barcelona also has the only Spanish researcher in Psychiatry.