Posts Tagged ‘CIBERDEM’

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Wednesday June 07th, 2017

A small group of neurons modulates the amount of insulin that the pancreas must produce

The brain is key in the regulation of appetite, body weight and metabolism. Specifically, there is a small group of hypothalamus neurons, called POMC, that detect and integrate signals that inform on the energy state of the organism and activate the appropriate physiological responses. These neurons are sensitive to fluctuations in nutrients such as glucose, fatty acids and amino acids.

Now, a research project co-chaired by Marc Claret, at the August Pi i Sunyer Biomedical Research Institute – IDIBAPS, and Antonio Zorzano, at the Institute for Research in Biomedicine (IRB Barcelona), both members of the CIBERDEM network, reveals the connection between POMC neurons at the hypothalamus and the release of insulin by the pancreas and describes new molecular mechanisms involved in this connection. The researchers publish the study in Cell Metabolism and the first authors are Sara Ramírez and Alicia G. Gómez-Valadés, both at IDIBAPS. Read the rest of this entry »

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Tuesday February 07th, 2017

Scientists discover that non-coding RNA regulates the expression of key genes in diabetes

Researchers at IDIBAPS and the Imperial College London publish a study in which they have discovered that RNA sequences that do not encode for proteins play a key role in the expression of certain genes in the beta cells of the pancreas. These genes are known to be involved in the development of different forms of diabetes. Dr. Jorge Ferrer, head of the team Genomic Programming of Beta Cells and Diabetes at IDIBAPS and at the Imperial College London and researcher at the Networked Biomedical Research Center for Diabetes and Associetaed Metabolic Diseases (CIBERDEM), coordinates this study published in the journal Cell Metabolism. Read the rest of this entry »

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Friday May 06th, 2016

Joel Montané is awarded with the Jose Antonio Hedo Prize from the Spanish Society of Diabetes

The Foundation of the Spanish Diabetes Society has awarded the Jose Antonio Hedo Prize on young basic research to Dr. Joel Montané, reasearcher at the the Pathogenesis and Prevention of Diabetes IDIBAPS group, for his scientific career in the field of diabetes. This group, which belongs to the Diabetes and Associated Metabolic Diseases (CIBERDEM) from CIBER, is led by Dr. Anna Novials and aims to generate new knowledge about the mechanisms of pathogenesis, prevention and treatment of diabetes.

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Monday November 11th, 2013

Cause of genetic disorder found in “dark matter” of DNA

For the first time, scientists have used new technology which analyses the whole genome to find the cause of a genetic disease in what has previously referred to as “junk DNA”. Pancreatic agenesis results in babies being born without a pancreas, leaving them with a lifetime of diabetes and problems digesting food. In a breakthrough for genetic research published by Nature Genetics, teams led by the University of Exeter Medical School and IDIBAPS – Imperial College London found that the condition is most commonly caused by mutations in a newly identified gene regulatory element in a remote part of the genome, which can now be explored thanks to advances in genetic sequencing. The first co-signers are Dr. Michael N. Weedon, from the University of Exeter, and Inês Cebola, from IDIBAPS and the Imperial College of London, while the co-directors of the study are Dr. Jorge Ferrer, head of the IDIBAPS Genomic Programming of Beta Cells and Diabetes, currently Chair in Genetics and Medicine at Imperial College London, and Dr. Andrew T. Hattersley, from the University of Exeter. The study has received, among others, support from the CIBER of Diabetes and Metabolic Diseases (CIBERdem).

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Friday January 20th, 2012

Can dogs detect hypoglycaemia and assist a patient during one of these episodes?

Dogs often show an altered behaviour when a crisis of hypoglycaemia is about to occur to one of his owners Read the rest of this entry »

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