A group of researchers led by professor Carles Enrich, Chief of IDIBAPS‘ Endocytosis and Protein Intracellular Transit team and member of Cellular Biology, Immunology and Neurosciences UB Dept., have found that cholesterol plays a key role in cell mobility and tissue invasion. The results of the study prove that the accumulation of LDL cholesterol cells —the one carried by low-density lipoproteins— may play a crucial role in promoting cell mobility. On the contrary, high levels of HDL cholesterol —the one carried by high-density lipoproteins— may avoid cell propagation. This is a key study to better understand cancer metastasis, the process in which cancer cells invade healthy tissues, and foster the discussion on the relationship between cholesterol levels and cancer incidence. The paper is published in open access Cell Reports.
Posts Tagged ‘Carles Enrich’
Results of the 26 projects about heart diseases funded by the 2007 TV3 Telethon presented in an academic event
The results of the 26 research projects on heart diseases which were funded by the TV3 Telethon 2007 were presented at the 14th Symposium of the TV3 Telethon Foundation (Fundació la Marató de TV3), which took place on June 20 at the Institut d’Estudis Catalans. The awarded researchers exposed to the scientific community and the general public the progresses in cardiovascular risk prevention, diagnosis and treatment of the heart diseases. Among the 26 projects, which are fruits of 7 M€ invested in cardiovascular diseases, there were 6 initiatives involving researchers from IDIBAPS.
The institutions from the IDIBAPS consortium receive 9 grants from the 2011 TV3 Telethon about regeneration and transplantation of organs and tissues
A total of 29 of biomedical research projects on regeneration and transplantation of organs and tissues have received 8 million euros from the 2011 TV3 Telethon. The 56 researchers who will lead these researches attended yesterday the awarding ceremony, held in the auditorium of the Historic Building of the University of Barcelona. Among them were nine researchers from IDIBAPS, who been awarded with a contribution of EUR 2.35 million for the next three years. Of the 9 grants for the Institutions in the IDIBAPS Consortium, IDIBAPS is the beneficiary of 4 and Fundació Clínic of 3 more, totaling 1.19 million Euros.
Three consecutive papers in Nature Protocols, EMBO Journal and Molecular Biology of the Cell position the IDIBAPS group Proliferation and cell signaling as a reference in the application of new advanced (Laurdan and confocal with two photons laser) and super- resolution (STED and TIRFM) optical microscopy techniques. The super-resolution microscopy, now available in very few leading centers like the National Center for Cardiovascular Research in Madrid or the Centre for Genomic Regulation in Barcelona, allows observations at the molecular level of cellular processes in vivo. The researchers of this team, with Dr. Carles Enrich and Dr. Carles Rentero from the Department of Cell Biology, Immunology and Neuroscience, of the Faculty of Medicine, University of Barcelona, in the lead, assure that these technologies will help to rewrite important chapters in cell biology and to understand the molecular basis of many diseases.
KRas is one of the usual suspects in cancer. It is a protein that is mutated in 30% of human tumors and has been implicated in the regulation of many cell signalling pathways. For this reason, it is one of the main focuses of attention of international basic research and it is difficult to publish new information relating to its molecular biology. Researchers from the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and the University of Barcelona (UB) have discovered a new breakdown pathway for this protein. The results, which could mean a new form of signalling involving KRas, were published in the latest edition of the Journal of Cell Biology (184(6):863-79), where they merited an appearance on the front page of the journal and an editorial comment. This study is part of the doctoral thesis of Dr. Albert Lu and includes the participation of Dr. Oriol Bachs, Dr. Carles Enrich, Dr. Neus Agell and Dr. Francesc Tebar, researchers from IDIBAPS and the Department of Cell Biology, Immunology and Neuroscience of the Faculty of Medicine of the University of Barcelona. Researchers from the University of Kyoto also took part in the study.