Posts Tagged ‘Augusto Villanueva’

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Tuesday February 19th, 2013

Notch signaling promotes liver carcinogenesis becoming an appealing target for new therapies

Less than 30% of newly diagnosed hepatocellular carcinoma (HCC) patients are eligible for curative therapies such as resection, liver transplantation, or local ablation. Hence, there is an increasing need to develop new drugs for a disease that, besides being the third leading cause of cancer death worldwide, has tripled its incidence in the last decades in the United States. An article published in Gastroenterology by the IDIBAPS Translational Research in Hepatic Oncology group, led by the ICREA investigator Prof Josep Maria Llovet, demonstrates that Notch signaling is activated in a subset of human HCC samples, and promotes liver tumor formation in genetically engineered mice. In addition, the study reports a Notch gene signature able to predict response to Notch inhibition in experimental models of liver cancer. First authorship of the manuscript is shared by Dr Augusto Villanueva and Clara Alsinet . The study is the result of an international collaboration that includes renown leaders in the field from the University of Pennsylvania (Philadelphia), the Broad Institute and Dana-Farber Cancer Institute at Harvard Medical School (Boston), and Mount Sinai School of Medicine (New York).

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Friday January 18th, 2013

Dr. Augusto Villanueva and Dr. Francesc Balaguer awarded Rising Stars by United European Gastroenterology (UEG) National Societies

Every year the United European Gastroenterology (UEG) National Societies Committee and the Scientific Committee jointly select up to 10 emerging clinical scientists. In the 2013 edition of the Rising Star awards two IDIBAPS investigators are among the winners: Dr. Augusto Villanueva, from the IDIBAPS Hepatocellular Carcinoma Translational Research Lab (BCLC group), and Dr. Francesc Balaguer, from the IDIBAPS Gastrointestinal and Pancreatic Oncology team.

The awarded researchers are young and highly qualified professionals from around Europe with a relevant international-quality research. This initiative provides a durable platform for young researchers so that they can give state-of-the-art lectures and chair scientific sessions at UEG Week. The next one will take place on October 12-16, in Berlin.

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Tuesday February 24th, 2009

A New Technology Identifies Genes Implicated in the Development of Liver Cancer.

Dr. Augusto Villanueva i Dr. Josep Mª Llovet

This study, published in the journal Nature Biotechnology and led by Dr. Josep Maria Llovet of Hospital Clínic de  Barcelona – IDIBAPS together with researchers from the University of Minnesota (USA), describes for the first time a new technology for genetic manipulation in experimental animals for identifying therapeutic targets that facilitate the development of drugs that improve patient outcome.

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