Archive for the ‘Research’ Category

Thursday January 26th, 2017

Scientists at Salk Institute have made breakthroughs in the integration of human cells into embryos of a different species

Human iPS cells (green) contributed to a developing heart of 4-week-old pig embryo (Image: Salk Institute)Scientists at Salk Institute for Biological Studies in California have made breakthroughs on multiple fronts in the race to integrate pluripotent stem cells from one species into the early-stage development of another. This will allow to study the embryonic development of an organism, diseases, test new therapeutic drugs and the possibly grow transplantable. Dr. Juan Carlos Izpisúa, professor in Salk’s Gene Expression Laboratory, leads this study published in today’s issue of the journal Cell. Dr. Josep M. Campistol, CEO and nephrologist in Hospital Clínic and researcher in IDIBAPS, and scientists from the Catholic University of Murcia (UCAM), the Pedro Guillén Foundation, the CEMTRO Clinic in Madrid and the University of Murcia, have also participated.

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Wednesday January 25th, 2017

A treatment increases survival by 50% in mice with Niemann-Pick type C, a rare disease that affects brain and liver

Researchers from the IIBB-CSIC and the IDIBAPS publish an article in the journal Redox Biology in which they propose an alternative treatment for Niemann-Pick disease type C, a rare lysosomal pathology that causes neurodegeneration and impaired liver function. With a compound that crosses the blood-brain barrier, it is possible to increase the survival of the mice by 50% and to improve the neurological and motor problems related to the disease. Dr. José C. Fernández-Checa, head of the IDIBAPS team on Mitochondrial regulation of cell death and steatohepatitis, and Dr. Carmen García-Ruiz, from the same team, are the coordinators of the study, which has been carried out in collaboration with researchers from France and Chile. The first author of the study is Sandra Torres, predoctoral researcher in Dr. Fernández-Checa’s lab.

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Tuesday January 17th, 2017

Researchers discover a protein that protects against fatty liver, the most common hepatic disease in Western countries

A team co-headed by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the IDIBAPS Biomedical Research Institute (part of the Hospital Clínic de Barcelona) has revealed the capacity of the CPEB4 protein to prevent fatty liver disease. This condition generally leads to chronic inflammation (non-alcoholic steatohepatitis), which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study on the basic biology of the liver paves the way to examine therapeutic strategies to fight and prevent fatty liver disease. The results have appeared in Nature Cell Biology this week.

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Monday January 16th, 2017

Hospital Clinic-IDIBAPS leads a European project to fight against cirrhosis within the Horizon 2020 program

Hospital Clínic-IDIBAPS is leading a European project to evaluate the efficacy of treatment with the combination of rifaximin, an antibiotic that modulates the intestinal microbiome, and statins in patients with advanced cirrhosis. The project, called LIVERHOPE, will also focuse on the search for biomarkers of the disease. LIVERHOPE is coordinated by Dr. Pere Ginès, head of the Hepatology Department of the Hospital Clínic and of the team of Mechanisms of liver diseases and complications of cirrhosis of IDIBAPS, and a total of 16 institutions are participating among clinical centers, universities and European companies. This project is part of the Horizon 2020 European research and innovation framework program and it is endowed with a budget of 6 million euros.

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Wednesday January 04th, 2017

A new drug has been developed for the treatment of autoimmune diseases

IDIBAPS researchers have participated in a study that shows how a new experimental drug could curb a wide variety of autoimmune diseases such as asthma, psoriasis, Crohn’s disease or multiple sclerosis without blocking the body’s natural response against infections caused by pathogens.

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Friday December 23rd, 2016

IDIBAPS is the Spanish biomedical center that has received more funds from Horizon 2020 in 2015

The European Commission has published the Horizon 2020 Monitoring report for 2015. This document includes, among others, the 50 institutions that have received the most funding for research in the calls made up to 2015.

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