Archive for the ‘Research’ Category

Saturday December 16th, 2017

A new combination of antibiotics allows treating 60% of hospital-acquired pneumonia

A study published in the journal The Lancet Infectious Diseases shows the ability of a new antibiotic (ceftazimida-avibactam) to treat hospital-acquired pneumonia, including ventilation-associated pneumonia. It has similar efficacy to one of the most used type of antibiotics in the treatment of this infection, carbapenems, but has the advantage of overcoming problems derived from its administration, such as the resistance of certain bacteria. Dr. Antoni Torres, Head of the Respiratory Intensive Surveillance Unit (UVIR) of the Hospital Clínic and head of the IDIBAPS team on Applied research in infectious respiratory diseases, critically ill patients and lung cancer, is the principal investigator of the study and first author of the article. Read the rest of this entry »

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Monday December 11th, 2017

Moderate exercise training improves some of the Marfan syndrome symptoms in mice

Regular physical activity is a common therapy for people with cardiovascular problems, but not recommended to those with Marfan syndrome, a rare disease of the connective tissue, but mainly affecting the cardiovascular system. A study conducted jointly by the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) has analysed for the first time this medical recommendation analysing the impact of exercise in the development of the disease in mice. The results, published in the scientific journal Journal of the American Heart Association, show that moderate exercise reduces the progression of the aortic aneurysm, one of the most severe symptoms of the disease which can cause arteries to break. Read the rest of this entry »

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Thursday October 26th, 2017

Computational Simulations Suggest Multiple Sclerosis is a Single Disease

IDIBAPS researchers publish a study in the journal Plos Computational Biology that supports the idea that multiple sclerosis (MS), which has widely varying symptoms and progression in different patients, is nonetheless a single disease with common underlying mechanisms. Pablo Villoslada, Head of the IDIBAPS group Pathogenesis and new treatments in Multiple Sclerosis, has coordinated the study. Ekaterina Kotelnikova, researcher at the same group, is the first author. Read the rest of this entry »

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Monday October 09th, 2017

IDIBAPS researchers describe the mechanism by which SOX11 promotes relapses in mantle cell lymphoma

Researchers at IDIBAPS publish an article in the Blood journal in which they show the mechanism by which the transcription factor SOX11 participates in the dissemination and aggressiveness of mantle cell lymphoma. They have discovered that SOX11 promotes the creation of a protective environment that ensures survival and resistance to treatments of tumor cells. The study was coordinated by Dr. Virginia Amador, researcher at the Human and experimental functional oncomorphology IDIBAPS team. Read the rest of this entry »

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Wednesday June 07th, 2017

A small group of neurons modulates the amount of insulin that the pancreas must produce

The brain is key in the regulation of appetite, body weight and metabolism. Specifically, there is a small group of hypothalamus neurons, called POMC, that detect and integrate signals that inform on the energy state of the organism and activate the appropriate physiological responses. These neurons are sensitive to fluctuations in nutrients such as glucose, fatty acids and amino acids.

Now, a research project co-chaired by Marc Claret, at the August Pi i Sunyer Biomedical Research Institute – IDIBAPS, and Antonio Zorzano, at the Institute for Research in Biomedicine (IRB Barcelona), both members of the CIBERDEM network, reveals the connection between POMC neurons at the hypothalamus and the release of insulin by the pancreas and describes new molecular mechanisms involved in this connection. The researchers publish the study in Cell Metabolism and the first authors are Sara Ramírez and Alicia G. Gómez-Valadés, both at IDIBAPS. Read the rest of this entry »

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Tuesday May 02nd, 2017

FreeOx Biotech acquires the rights of two compounds to treat neurological and cardiovascular diseases

Dr. Ángel Chamorro, Head of the Functional Unit of Cerebral Vascular Pathology at Hospital Clínic de Barcelona, ​​has developed two compounds with neuroprotective properties based on reducing the effects of oxidative stress on the body. Hospital Clínic and the Clínic Foundation for Biomedical Research, with the support of the IDIBAPS’s KTT office (Knowledge and Technology Transfer), have signed an exclusive license agreement with FreeOx Biotech for the development and exploitation of this technology. Read the rest of this entry »

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