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Tuesday March 07th, 2017

The European project LifeBrain will analyze the keys of cognitive ageing with data from more than 6.000 people

The European project LifeBrain has been set up this year. This is a project funded with ten million euros by the European Union program Horizon 2020, and which will last five years, aiming to identify risk and protective factors in the brain and mental health during different life stages. The project counts with the participation of fourteen research groups from different European countries –mainly Scandinavian- coordinated by the University of Oslo. The only group representing southern Europe is led by David Bartrés Faz, researcher from the Institute of Neurosciences of the University of Barcelona and IDIBAPS and coordinator of the Barcelona Brain Stimulaiton Lab (BBSLab). Read the rest of this entry »

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Friday February 17th, 2017

A therapeutic HIV vaccine clinical trial induces viral control in 5 people without taking antiretroviral therapy

A therapeutic HIV vaccine clinical trial showed, for the first time, that in some cases the immune system of HIV infected people can be reeducated to control the virus for long periods without taking antiretroviral treatment. In particular, 5 out of 13 participants who stopped treatment (38.5%) have been controlling the virus for 5, 13, 17, 20 and 27 weeks, respectively. The study, still ongoing, is conducted in Barcelona and tests a vaccine developed by researchers at Oxford University in combination with a drug, romidepsin, able to awaken latent viruses in the body. The study is conducted by IrsiCaixa and the Fight AIDS Foundation and performed at the ospital Clínic de Barcelona-IDIBAPS, the Germans Trias i Pujol University Hospital (Barcelona) and the community center BCN Checkpoint. Read the rest of this entry »

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Wednesday February 15th, 2017

IDIBAPS participates in an European project to enable personalized therapies in multiple sclerosis

A global partnership, coordinated by the Karolinska Institutet and in which IDIBAPS researchers participate, has received 15 million euros from the European Commission framework program Horizon2020 to find new and improved treatments for Multiple Sclerosis (MS). This project, named MultipleMS, involves universities and companies from 12 European countries and the USA, which will join efforts to adapt the development and application of therapies to each MS patient.

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Tuesday February 07th, 2017

Scientists discover that non-coding RNA regulates the expression of key genes in diabetes

Researchers at IDIBAPS and the Imperial College London publish a study in which they have discovered that RNA sequences that do not encode for proteins play a key role in the expression of certain genes in the beta cells of the pancreas. These genes are known to be involved in the development of different forms of diabetes. Dr. Jorge Ferrer, head of the team Genomic Programming of Beta Cells and Diabetes at IDIBAPS and at the Imperial College London and researcher at the Networked Biomedical Research Center for Diabetes and Associetaed Metabolic Diseases (CIBERDEM), coordinates this study published in the journal Cell Metabolism. Read the rest of this entry »

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Thursday February 02nd, 2017

Hospital Clinic-IDIBAPS coordinates a European project to obtain a functional cure for HIV with immunotherapy

The IDIBAPS and the Hospital Clínic of Barcelona lead a European project aimed at changing the current paradigm of HIV treatment by obtaining a functional cure. The main goal is to control HIV replication over long periods of time or throughout life without antiretroviral treatment. Dr. Felipe Garcia, senior consultant of the Infectious Diseases Department at Hospital Clínic and researcher of the IDIBAPS team on Infectious Diseases and AIDS, coordinates this study called HIVACAR. This initiative is part of the European research and innovation framework program Horizon 2020, has a total budget of 6.7 million euro and 14 institutions will participate, among clinical and research centers and European companies. In Spain, the other participating institutions are the IrsiCaixa AIDS Research Institute, the National Center for Biotechnology (CNB-CSIC) and the Faculty of Economics and Business Sciences of the Complutense University of Madrid (UCM). Read the rest of this entry »

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Friday January 27th, 2017

IDIBAPS researchers review recent advances in rapid and effective treatment of depression

Drs. Francesc Artigas and Analía Bortolozzi, researchers of the team of Neuropharmacology and Experimental Neuropathology in the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and the IIBB-CSIC, have just published a “Hot Topic” article in the first issue of 2017 in the journal Neuropsychopharmacology, one of the most prestigious in the field of Psychiatry and Neuropharmacology. This section of the journal, published at the beginning of each year, collects significant advances recently produced in the field.

The article briefly reviews the advances made by the group in the development of new experimental strategies for a more rapid and effective treatment of depression through the use of interfering RNA molecules conjugated to serotonin reuptake inhibitors. These advances were published in the journals Molecular Psychiatry and Traslational Psychiatry and show that these conjugates produce an antidepressant effect faster than the conventional drugs in experimental models, which means a remarkable advance with a possible therapeutic application.

Article reference:

Therapeutic Potential of Conjugated siRNAs for the Treatment of Major Depressive Disorder
Artigas F, Bortolozzi A.
Neuropsychopharmacology. 2017 Jan;42(1):371. doi: 10.1038/npp.2016.182.

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