Archive for the ‘Research’ Category

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Wednesday June 07th, 2017

A small group of neurons modulates the amount of insulin that the pancreas must produce

The brain is key in the regulation of appetite, body weight and metabolism. Specifically, there is a small group of hypothalamus neurons, called POMC, that detect and integrate signals that inform on the energy state of the organism and activate the appropriate physiological responses. These neurons are sensitive to fluctuations in nutrients such as glucose, fatty acids and amino acids.

Now, a research project co-chaired by Marc Claret, at the August Pi i Sunyer Biomedical Research Institute – IDIBAPS, and Antonio Zorzano, at the Institute for Research in Biomedicine (IRB Barcelona), both members of the CIBERDEM network, reveals the connection between POMC neurons at the hypothalamus and the release of insulin by the pancreas and describes new molecular mechanisms involved in this connection. The researchers publish the study in Cell Metabolism and the first authors are Sara Ramírez and Alicia G. Gómez-Valadés, both at IDIBAPS. Read the rest of this entry »

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Tuesday May 02nd, 2017

FreeOx Biotech acquires the rights of two compounds to treat neurological and cardiovascular diseases

Dr. Ángel Chamorro, Head of the Functional Unit of Cerebral Vascular Pathology at Hospital Clínic de Barcelona, ​​has developed two compounds with neuroprotective properties based on reducing the effects of oxidative stress on the body. Hospital Clínic and the Clínic Foundation for Biomedical Research, with the support of the IDIBAPS’s KTT office (Knowledge and Technology Transfer), have signed an exclusive license agreement with FreeOx Biotech for the development and exploitation of this technology. Read the rest of this entry »

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Thursday April 20th, 2017

A study reveals the biological changes in breast cancer between the primary tumor and metastases

A study published in the journal Cancer Research underscores the importance of the molecular characterization of the metastases in breast cancer. Researchers have described, for the first time, that the longer the time from the onset of the tumor to the development of metastasis is, the more aggressive this cancer becomes. They have also shown that between the initial tumor and the metastasis the subtype of breast cancer can change in up to 40% of cases. The work has been coordinated by Aleix Prat, Head of the Oncology Department of the Hospital Clínic, Head of the Translational Genomics team and directed therapies in solid tumors IDIBAPS team and Head of the VHIO Translational Genomics Group. The first author of the study is Juan Miguel Cejalvo, PhD student of the PhD4MD program in the group led by Aleix Prat at IDIBAPS and in the Growth Control and Cancer Metastasis group of the Institute for Research in Biomedicine (IRB Barcelona), led by the ICREA researcher Roger Gomis.

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Friday March 31st, 2017

IDIBAPS hosts the meeting of the HEP-CAR european project on hepatocarcinoma and co-morbidities

On 13 March, IDIBAPS hosted the annual meeting of the European HEP-CAR consortium. The aim of the project is to identify the molecular mechanisms involved in the development of hepatocellular carcinoma (HCC) and their role in the different co-morbidities that induce the onset of this type of cancer: the infection by hepatitis B and C viruses, alcohol intake or obesity. Translational Reserarch in Hepatic Oncology IDIBAPS group, led by Dr. Josep M. Llovet, in collaboration with Dr. Roser Pinyol and 8 more researchers, participates in this research intiative.
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Tuesday March 21st, 2017

An International study proves that Huntington’s disease alters neurons since they start developing

 

Huntington’s disease could alter neurons since they start developing, according to a study conducted by the international HD iPSC Consortium, which counts with the participation of the team of the Laboratory of Stem Cells and Regenerative Medicine of the Department of Biomedicine of the Faculty of Medicine and Health Sciences of the UB, led by Josep M. Canals, from the Faculty of Medicine and Health Sciences of the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS). The study, published in the scientific journal Nature Neuroscience, counts with the collaboration of the experts of the UB Mónica Pardo, Gerardo García, Marco Straccia, Phil Sanders and Jordi Alberch. Read the rest of this entry »

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Thursday March 16th, 2017

IDIBAPS and IRB Barcelona researchers create viruses to selectively attack tumor cells

Scientists at the IDIBAPS Biomedical Research Institute and at the Institute for Research in Biomedicine (IRB Barcelona) lead a study in which they have designed a new strategy to get genetically modified viruses to selectively attack tumor cells without affecting  healthy tissues. The study, published today by the journal Nature Communications, is part of Eneko Villanueva’s work for his PhD and it is co-lead by Cristina Fillat, head of the Gene Therapy and Cancer Group at IDIBAPS, and Raúl Méndez, ICREA researcher at IRB Barcelona. Read the rest of this entry »

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