Archive for the ‘IDIBAPS’ Category

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Friday April 17th, 2009

New data on the breakdown of the KRas protein

D'esq. a dreta: el Dr. Carles Enrich, el Dr. Albert Lu i el Dr. Oriol Bachs.

KRas is one of the usual suspects in cancer. It is a protein that is mutated in 30% of human tumors and has been implicated in the regulation of many cell signalling pathways. For this reason, it is one of the main focuses of attention of international basic research and it is difficult to publish new information relating to its molecular biology. Researchers from the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and the University of Barcelona (UB) have discovered a new breakdown pathway for this protein. The results, which could mean a new form of signalling involving KRas, were published in the latest edition of the Journal of Cell Biology (184(6):863-79), where they merited an appearance on the front page of the journal and an editorial comment. This study is part of the doctoral thesis of Dr. Albert Lu and includes the participation of Dr. Oriol Bachs, Dr. Carles Enrich, Dr. Neus Agell and Dr. Francesc Tebar, researchers from IDIBAPS and the Department of Cell Biology, Immunology and Neuroscience of the Faculty of Medicine of the University of Barcelona. Researchers from the University of Kyoto also took part in the study.

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Thursday April 16th, 2009

IDIBAPS at the Live Research Fair

20090416_recerca_en_directeLa Pedrera became a huge laboratory on 15 and 16 April. Barcelona Science Park (Parc Científic de Barcelona) organized the 7th edition of the Live Research Fair (Fira en Directe), an initiative to explain the work of Catalan research centers to the public. Over the course of two days, more than 10 centers explain some of their lines of research to visitors to the fair. Many active researchers explain what they do and invite the public to interact with elements relating to their work.In this edition, IDIBAPS worked with the Respiratory Immunology-Allergy Unit. At our stand, Dr. Aida Herrerias and Mariona Serra presented their research on the treatment of asthma, a disease that affects more than 300 million people and for which there is, as yet, no effective treatment. Using explanatory posters, videos explaining the experimental model and a microscope provided by Olympus, visitors were able to gain a greater understanding of this disease and what is being done to combat it.

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Thursday April 09th, 2009

Early Administration of Antiretroviral Therapy Can Improve Survival

 Dr. Josep Maria Miró during the pres meeting at the Hospital Clínic

The first antiretroviral treatments appeared in 1996. Since then, new and better drugs have been discovered that have almost turned AIDS into a chronic disease. Nevertheless, there is still room to improve the performance of the the therapeutic strategies used in clinical practice. This is shown by a study published in the online edition of The Lancet, suggesting that early administration of antiretroviral treatment reduces the rate of AIDS development and death in HIV-positive patients by 28%. This study analyzed information from more than 45,000 patients in Europe and North America and combined data from 15 international cohorts. One of these is the PISCIS Catalan and Balearic cohort, coordinated by Dr. Jordi Casabona of the Centre for Epidemiologic Studies of Sexually Transmitted Diseases and AIDS in Catalonia (CEEISCAT) – Catalan Institute of Oncology (ICO), and by Dr. Josep María Miró of the Infectious Diseases Department of Hospital Clínic – IDIBAPS, University of Barcelona. Dr. Josep María Miró is the only Spaniard in the international When to Start Consortium, which has taken part in writing and signing the article. Professor Jonathan Sterne of the University of Bristol (UK) is the first author.

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Monday April 06th, 2009

Psychoeducation is Beneficial in the Long Term in Bipolar Disorder

Dr. Eduard Vieta and Dr. Francesc Colom, second and first authors, respectively

A 6-month psychoeducational strategy achieves beneficial effects that last more than 5 years. Patients who took part in the psychoeducation sessions suffered 66% fewer episodes of mania and 75% fewer episodes of depression. This represents preventing a year of symptoms over 5 years. The cost-benefit analysis shows that the use of health care resources is far lower in these groups than in those that do not carry out the initial follow-up. Hospital Clínic de Barcelona is a pioneer both in the application of this treatment and in training professionals qualified to carry it out.

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Friday April 03rd, 2009

IIS Clínic-IDIBAPS Holds a Conference on Neurosciences in Conjunction with the IRB and Sant Joan de Déu

IIS Workshop Clínic-IDIBAPS on Neurosciences

Last week, on 26 and 27 March, the second meeting of the Clínic-IDIBAPS Institute for Health Care Research was held at the Hilton Diagonal hotel. On this occasion, the conference took a closer look at research in neuroscience, with the aim of exchanging knowledge with other pioneering centers such as the Barcelona Institute for Biomedical Research and Hospital Sant Joan de Déu. The conference dealt with different diseases (Alzheimer, Parkinson, schizophrenia and other neurodegenerative and psychiatric diseases) from the different levels of research, from basic to clinical, placing special emphasis on translational research.

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Protein Trafficking to the Liposomes is Abnormal in Huntingdon Disease

Dr. Josep Maria canals and Daniel Del Toro at the UB Medicine Faculty

Huntingdon disease is a hereditary neurodegenerative disease that progressively and specifically destroys the cerebral cortex and basal ganglia, where the most affected cells are the neurons of the corpus striatum. This disease presents between the ages of 30 and 50 years and is characterized by cognitive and motor disorders. The most characteristic trait is exaggerated movement of the limbs, which lead to completely incapacitating behavior by the patient.

The disease is caused by a mutation of the huntingtin protein, which is widely distributed throughout the cells. Huntingtin is located in the Golgi apparatus and in the transport vesicles. It interacts with intracellular motors and allows movement of the vesicles within the cell. The mutation of the protein consists of an abnormal increase of more than 35 repetitions of glutamine at the N-terminal. The molecular mechanisms that lead this mutation of huntingtin to cause neuron dysfunction and death, particularly in neurons of the corpus striatum are not understood.

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