Archive for the ‘IDIBAPS’ Category

Friday February 27th, 2009

Principal Cause of Cerebral Atrophy in Multiple Sclerosis Unknown.

Dr. Pablo Villoslada

Until now, it was thought that the lesions or plaques observed in the white matter were the cause of the damage to the brain. New data indicates that these plaques account for only 30% of the atrophy in the grey matter; other unexplained neurodegenerative mechanisms are therefore also implicated. Read the rest of this entry »

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Tuesday February 24th, 2009

A New Technology Identifies Genes Implicated in the Development of Liver Cancer.

Dr. Augusto Villanueva i Dr. Josep Mª Llovet

This study, published in the journal Nature Biotechnology and led by Dr. Josep Maria Llovet of Hospital Clínic de  Barcelona – IDIBAPS together with researchers from the University of Minnesota (USA), describes for the first time a new technology for genetic manipulation in experimental animals for identifying therapeutic targets that facilitate the development of drugs that improve patient outcome.

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Wednesday February 18th, 2009

The TRPV4 receptor plays a key role in the death of pancreatic cells induced by amyloid fibers

Anna Novials

Amyloid is a pathologic substance mostly consisting of proteins such as amylin, which can become deposited on different organs and tissues. In some degenerative diseases, such as Alzheimer’s or Parkinson’s, the formation of ordered amyloid fibers has been observed in places where cell death occurs. In patients with type-2 diabetes mellitus, islets of amyloid have been found within the islets of Langerhans, the collection of pancreatic cells with an endocrine function. These amyloid deposits are found in regions with cellular degeneration and have therefore been associated with the progression of the diabetes.

An IDIBAPS study published on the front page of Diabetologia (51(12):2252-62) by the team led by Dr. Anna Novials analyzes the mechanisms by which these amyloid fibers are associated with the death by apoptosis of pancreatic cells. The results show that abnormal concentrations of calcium play a key role in the toxicity induced by the amyloid. The hypothesis put forward in the article suggests that TRPV4, a channel to the cell surface that is sensitive to mechanical and osmotic changes, becomes activated in response to physical alterations caused by the aggregation of fibers around the cells. This would activate the process that leads to cell death by apoptosis: the entry of calcium into the cell, that the polarized nation of the membrane, and the activation of L-type calcium channels.

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Tuesday February 17th, 2009

New European consensus document for management of hospital pneumonia

Dr. Antoni Torres

Considerable disagreement persists regarding hospital-acquired pneumonia and ventilator-associated pneumonia. This circumstance has led to the initiative to create a consensus document that unifies the criteria of the 3 main European societies linked to these diseases—the European Respiratory Society (ERS), the European Society of Clinical Microbiology and Infectious Diseases and the European Society of Intensive Care Medicine. The person chosen to coordinate this project and represent the ERS was Dr. Antoni Torres, head of the respiratory medicine department of Hospital Clínic, Barcelona and leader of the research team on the spiritual diseases at the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). He is the principal author of the article published in the Journal Intensive Care Medicine (35:9-29), which lists the 20 points of agreement that were reached.

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Thursday January 22nd, 2009

The First Scientific Meeting of the IIS Clínic-IDIBAPS with the IRB Focuses on Cancer

The meeting was held at hotel HiltonThe Institute for Health Care Research (IIS) Clínic-IDIBAPS is a new body that was created as a result of the accreditation of our center by the Ministry of Science and Innovation. The first scientific  meeting under the umbrella of the strategic alliance, which joins the efforts of this new institute with those of the IRB, was held on 22 January. The theme of the meeting was  cancer and this allowed scientists from IDIBAPS-Clínic and the IRB to share experiences and approaches during an intense conference held at the Barcelona Hilton Hotel.

The aim of this initiative is to encourage the creation of networks of cooperation between the two institutions. New themed meetings of this type will be held over the coming months. The 3 planned themes are: Neurosciences; hepatic and metabolic diseases; and Infectious diseases, research on international health and immunology. It is necessary to continue to join forces to make the research done in Barcelona, Catalonia and Spain increasingly competitive at international level.

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Thursday January 15th, 2009

The CD5 Molecule Helps to Combat Septic Shock Caused by Fungi

Dr. Francisco Lozano and Dr. Jorge Vera

Septic shock is a serious medical condition caused by an infection that spreads in an uncontrolled manner throughout the body via the circulatory system. It produces severe inflammatory symptoms with cardiovascular failure caused by particularly virulent bacterial or fungal toxins in the blood. It is the main cause of death in intensive care units, with a mortality rate of between 30% and 50% of patients who suffer from it.

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