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Tuesday March 17th, 2009

Science, Technology and IDIBAPS at Saló de l’Ensenyament 2009

Virtual Olympics al Salo de l'Ensenyament
This year’s edition of Saló de l’Ensenyament is being held from 18 to 22 March. This fair is already a classic event for those who have not yet decided what to study in the future or who want to broaden their education. The fair provides the most complete range of resources for taking decisions, with representatives from many areas of teaching, such as secondary education, vocational training, university studies, complementary studies, languages, occupational training and education services.

Of note is the creation of the Science and Technology Zone, which opens a door onto the work of universities, research centers, businesses, technological associations, etc. The aim of this area is to provide a close-up view of the results of scientific research and technological innovation. IDIBAPS is present at the EventLab stand, where you will find representatives of the Systems Neuroscience team led by María V. Sánchez-Vives.

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Monday March 09th, 2009

The Journals PNAS and Gastrointestinal Endoscopy Acknowledge the Work of the Researchers of Hospital Clínic – IDIBAPS

Articles reconeguts a PNAS i Gastrointestinal Endoscopy

The number and quality of the articles signed by researchers from Hospital Clínic and IDIBAPS continues to grow. There have been 2 recent examples of how this work has been receiving considerable international recognition.

First, the prestigious journal Proceedings of the National Academy of Science (PNAS) dedicated a 2-page illustrated commentary on the print edition of an article that appeared online in mid-January. This underlines the relevance of the results presented in the article, which described the efficacy of CD5 protein to treat septic shock caused by fungi. This study was carried out in collaboration with Hospital del Mar, Universidad Complutense, Madrid, and East Tennessee State University and, together with previous complementary research by the team, could become the first effective response to fungal and bacterial septic shock. The study was coordinated by Dr. Francisco Lozano and the main authors were Dr. Jorge Vera and Dr. Rafael Fenutria.

Also, the journal Gastrointestinal Endoscopy, one of the most important journals worldwide in the area of gastroenterology, has congratulated the authors of research published in September 2008. The article became the 11th most viewed online through Sciencedirect. This study on the treatment of gastric vascular lesions was signed by Dr. Samuel Herrera and Dr. Josep M. Bordas (main authors) and by Dr. Antoni Castells.

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Thursday March 05th, 2009

IDIBAPS Receives Accreditation as a Health Care Research Institute from the Ministry of Science and Innovation

L'IDIBAPS, acreditat pel IIS

Accreditations for Health Care Research Institutes were awarded for the first time at an event held today at the Carlos III Health Institute in Madrid. The Institute d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) – Hospital Clínic, Barcelona was the first center to be accredited and this fact has now been formalized. A further 3 Catalan centers have now joined IDIBAPS – the research institutes of the Vall d’Hebron, Bellvitge and Germans Trias i Pujol hospitals. Apart from the 4 Catalan hospitals, the Biomedicine Institute of Seville (IBIS) has also been accredited.

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Friday February 27th, 2009

Principal Cause of Cerebral Atrophy in Multiple Sclerosis Unknown.

Dr. Pablo Villoslada

Until now, it was thought that the lesions or plaques observed in the white matter were the cause of the damage to the brain. New data indicates that these plaques account for only 30% of the atrophy in the grey matter; other unexplained neurodegenerative mechanisms are therefore also implicated. Read the rest of this entry »

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Tuesday February 24th, 2009

A New Technology Identifies Genes Implicated in the Development of Liver Cancer.

Dr. Augusto Villanueva i Dr. Josep Mª Llovet

This study, published in the journal Nature Biotechnology and led by Dr. Josep Maria Llovet of Hospital Clínic de  Barcelona – IDIBAPS together with researchers from the University of Minnesota (USA), describes for the first time a new technology for genetic manipulation in experimental animals for identifying therapeutic targets that facilitate the development of drugs that improve patient outcome.

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Wednesday February 18th, 2009

The TRPV4 receptor plays a key role in the death of pancreatic cells induced by amyloid fibers

Anna Novials

Amyloid is a pathologic substance mostly consisting of proteins such as amylin, which can become deposited on different organs and tissues. In some degenerative diseases, such as Alzheimer’s or Parkinson’s, the formation of ordered amyloid fibers has been observed in places where cell death occurs. In patients with type-2 diabetes mellitus, islets of amyloid have been found within the islets of Langerhans, the collection of pancreatic cells with an endocrine function. These amyloid deposits are found in regions with cellular degeneration and have therefore been associated with the progression of the diabetes.

An IDIBAPS study published on the front page of Diabetologia (51(12):2252-62) by the team led by Dr. Anna Novials analyzes the mechanisms by which these amyloid fibers are associated with the death by apoptosis of pancreatic cells. The results show that abnormal concentrations of calcium play a key role in the toxicity induced by the amyloid. The hypothesis put forward in the article suggests that TRPV4, a channel to the cell surface that is sensitive to mechanical and osmotic changes, becomes activated in response to physical alterations caused by the aggregation of fibers around the cells. This would activate the process that leads to cell death by apoptosis: the entry of calcium into the cell, that the polarized nation of the membrane, and the activation of L-type calcium channels.

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