The anti-NMDA autoimmune encephalitis is a disease described in 2005 by a team led by Dr. Josep Dalmau at the University of Pennsylvania (USA). In this disorder the patient’s immune system attacks the NMDA receptors in the brain, which are important for neuronal plasticity. It triggers a wide range of symptoms such as psychosis, behavioral disturbances, memory deficit or loss of consciousness that may be confused with severe psychiatric disorders. The disease affects mainly women, especially young ones. Nowadays Dr. Josep Dalmau heads, thanks to a senior ICREA contract, the Autoimmunity against synaptic antigens IDIBAPS group. In collaboration with colleagues at the University of Pennsylvania, where he keeps collaborating, and other international partners, his team published in Lancet Neurology the keys to successfully treat over 80% of these patients. The first author is Dr. Maarten Titulaer, a Dutch researcher who works at Dr. Dalmau’s IDIBAPS team.
Archive for the ‘Hospital Clínic’ Category
The plenary session of the Institute of Catalan Studies (Institut d’Estudis Catalans – IEC) agreed on February 25 to include four new members. The columnist, enigmist, storyteller and translator Màrius Serra and the teacher Vicent Pascual, who played a key role in the introduction of Catalan in the Valencian school in the last thirty years, joined the Philological Section. Doctors Jordi Salas-Salvadó, from the Hospital Universitari Sant Joan de Reus, and Ramon Gomis, Director of IDIBAPS, joined the Biological Sciences Section.
The Mediterranean diet supplemented with extra virgin olive oil or nuts, is able to reduce by 30% the risk of myocardial infarction, stroke or cardiovascular death, according to the results obtained by Spanish investigators after nearly ten years of research. The study, published today in The New England Journal of Medicine, represents the successful culmination of PREDIMED, a project that started in 2003 with funding from the Carlos III Health Institute (ISCIII), a institution from the Ministry of Research, Development and Innovation of the Spanish Ministry of Economy and Competitividad. The study has received a total funding close to eight million euros, of which seven have been provided by the ISCIII.
The Secretary of State for Research, Development and Innovation, Carmen Vela, presided in Madrid the presentation of the results, that were explained by Dr. Ramon Estruch, leader of the group that has coordinated PREDIMED from Hospital Clínic – IDIBAPS of Barcelona and the University of Barcelona. Simultaneously, the head of the rest of the groups, Dr. Miguel Angel Martinez-Gonzalez, from the University of Navarra, has unveiled the same results at the International Congress of Nutrition being held these days in Loma Linda, California.
Haemodialysis is a technique that replaces the functions of the kidney in filtering blood in patients with terminal-phase kidney disease. Despite the advances that have been made in recent decades, the annual mortality among these patients can be 15-25%. A study sponsored by the Catalan Society of Nephrology (Societat Catalana de Nefrologia) shows for the first time that OL-HDF improves the survival and quality of life of patients who need haemodialysis. This technique increases the removal of uraemic toxins and reduces mortality by 30% after three years. The study, published today in the Journal of the American Society of Nephrology (1), involved 27 centres in Catalonia and 906 patients. The lead author and principal investigator of the study is Dr Francesc Maduell, head of the Dialysis Unit of the Nephrology Department at Hospital Clínic in Barcelona.
According to a recent article in the magazine: Molecular and Cellular Proteomics, a series of experiments suggest that sperm can get the ATP (adenosine triphosphate) that gives them the energy to move, from the fatty acid metabolized by peroxisomal and mitochondrial pathways. To know that these metabolic enzymes are in human sperm would mean a significant progress in the knowledge of the metabolism of spermatozoa. The study has been carried out by Dr. Alexandra Amaral, Dr. Rafael Oliva, and Dr. Josep Lluís Ballesca, from the Research Group Human Genetics IDIBAPS, Hospital Clínic and the Department of Physiological Sciences, Faculty of Medicine University of Barcelona. Dr. Oliva also heads the Marie Curie Initial Training Network REPROTRAIN (Reproductive Biology Early Research Training), funded by the European Commission, which aims to train a new generation of researchers in Male Reproductive Biology and Andrology. Read the rest of this entry »
Dr. Jordi Bruix leads a document that establishes radiological diagnostic criteria for hepatocellular carcinoma in the US
The American Society of Radiology publishes in its journal Radiology an updated article summarizing the new recommendations to diagnose and follow patients with hepatocellular carcinoma considered for liver transplantation in the United States. The document is the result of a task force created in 2008 in the heart of an expert conference organized by UNOS (the american organ distribution agency). Dr. Jordi Bruix, head of the Hepatic Oncology IDIBAPS – Hospital Clínic research team, participated as an international expert in the field of diagnosis and treatment of liver cancer. He is the last author of this document that defines the strategy in the US, which includes other internationally renowned experts from institutions such as Tufts University Medical School, Carolinas Medical Center, Mayo Clinic and University of Michigan Hospital.