In developing economies, there are patients in whom pacemaker implantation is delayed because they cannot afford one. Reused devices have been a solution. To address concerns about safety, a cohort of consecutive patients implanted with a reused pacemaker was compared with a control group. This research was conducted in the Department of Electrocardiology at the Instituto Nacional de Cardiología Ignacio Chávez (México), and counted with the collaboration of the Department of Cardiology at Hospital Clínic – IDIBAPS of Barcelona. The last authors of the article published in Circulation are Dr. Josep Brugada, Medical Director at the Hospital Clínic and team leader at IDIBAPS, and Dr. Pedro Iturralde, head of the Electrocardiology Department at the Mexican center.
Archive for the ‘Hospital Clínic’ Category
Reuse of pacemakers is a good solution to make these devices more accessible in developing economies
Idiopathic rapid-eye-movement sleep behaviour disorder is the prodromal phase of neurodegenerative diseases
A series of works, led from the Neurology Service at the Hospital Clínic – IDIBAPS of Barcelona, show that idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) represents the prodromal phase of neurodegenerative diseases, such as dementia with Lewy bodies (DLB) or Parkinson’s disease (PD). Patients suffering REM sleep behaviour disorders dream nightmares in which they are attacked and pursued, with the particularity that they express them by screaming, crying, punching and kicking while sleeping. Lancet Neurology has published four consecutive works about the relationship between this disorder and Parkinson’s disease. The first author of these articles is Dr. Àlex Iranzo, doctor from the Neurology Service at the Hospital Clínic of Barcelona and researcher at the IDIBAPS and member of the Multidisciplinary Sleep Disorders Unit, and the senior authors were to Dr. Joan Santamaria and Dr. Eduard Tolosa, from the same institution.
Bipolar disorder is characterized by the alternation of manic, depressive and mixed episodes. The nature of mixed mood episodes is still a matter of controversy amongst experts. Currently, the approach to this syndrome is mainly categorical and very restrictive. Mood episodes tend to cluster together within different symptom complexes, which can co-exist in individual patients. This approach is termed dimensional or factorial. While the factor structure of scales assessing schizophrenia has been thoroughly investigated, the factor-structure of bipolar mood episodes has not been studied yet.
Investigators from the Bipolar Disorders Programme at IDIBAPS – Hospital Clínic published recently in the Journal of Affective Disorders (1) a dimensional analysis of the structure of bipolar episodes aimed at identifying a factor deconstructing mixed episodes. Dr. Eduard Vieta and Dr. Francesc Colom are the last authors of the article, while Dr. Isabella Pacchiarotti is the first one. The team led by Dr. Vieta is an influential international group, as reflected in the fact that he participated in the Editorial commenting the update of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in The American Journal of Psychiatry (2). According to Nature (3), this update is one of the 10 key findings and events that may emerge in 2013.
Dr. Jaume Bosch, receives the Lilly Foundation Biomedical Research 2013 Award in the category of clinical research
The Lilly Foundation has awarded the Biomedical Research Awards 2013 in the categories of preclinical and clinical research, respectively, to Dr. Andrés Moya, scientific director of the Centre Superior d’Investigació en Salut Pública de la Conselleria de Sanitat de la Generalitat Valenciana (CSISP-FISABIO), and Dr. Jaume Bosch, scientific director of CIBER of Hepatic and Digestive Diseases (CIBERehd) and professor of medicine at the Hospital Clínic – IDIBAPS of Barcelona. These awards, endowed with an amount of € 40,000 each, recognize excellence scientific career of researchers who have contributed to the development of Biomedicine and Health Sciences in Spain.
Glucagon like peptide-1 (GLP-1) is a gut hormone related to insulin sensitivity. It has been suggested as a major factor for the improved glucose tolerance ensuing after Roux-en-Y Gastric Bypass (RYGBP) surgery. In this procedure, a stomach pouch is connected directly to the small intestine just beyond the duodenum. The remaining small intestine, with the rest of the stomach attached, is connected into a lower part of the intestine creating the “Y” shape that gives the technique its name. A work published in Diabetes Care suggests that the resolution of type 2 diabetes after RYGBP may be explained by mechanisms beyond enhancement of GLP-1 action. The first author of the paper is Dr. Amanda Jiménez, and Dr. Josep Vidal is the latter, both from the IDIBAPS team Diabetes: metabolic and molecular networks and the Endocrinology Service of the Hospital Clínic of Barcelona directed by Dr. Vidal.
Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukemia, co-led by Dr. Elías Campo, links for the first time cancer with errors in the protection of chromosomes
A research published by Nature Genetics explores a new mechanism that may contribute to the development of diverse tumors, including chronic lymphatic leukemia, a form of cancer that affects thousands of new patients each year in Spain. The researchers have detected for the first time in a human cancer the mutation of an essential gene for the protection of the telomeres, situated on the edges of the chromosomes. The research, directed by Carlos López-Otín, of the University Institute of Oncology of the University of Oviedo, Elías Campo, of the Clínic Hospital/University of Barcelona, and María Blasco, director of the National Center of Oncological Research (CNIO), breaks new ground for the Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukemia.