The journal Neuropsychopharmacology, from the Nature group, recently published an article that describes a dysregulation of the main components of the peripheral endocannabinoid system in patients with a first psychotic episode, comparing them with a large sample of healthy controls. After controlling for age, gender, body mass index, and cannabis use, the patient group showed a significantly reduced expression of the main enzymes of endocannabinoid synthesis and increased expression of those degrading them. The subgroup of patients with a history of cannabis showed a significant lower expression of some markers, compared with the control group. The first author of the study is Dr. Miquel Bioque and the last one is Dr. Miguel Bernardo, both members of the Schizophrenia Unit of the Hospital Clinic and the IDIBAPS team Biological bases of psychiatric disorders and nuclear psychiatry.
Archive for the ‘Hospital Clínic’ Category
Psychiatrists and basic scientists describe a dysregulation of the peripheral endocannabinoid system in first psychotic episodes
Cardiac-resynchronization therapy is not useful in patients with systolic heart failure and a narrow QRS
A work published in New England Journal of Medicine demonstrates how Cardiac-resynchronization therapy does not reduce the rate of death or hospitalization for heart failure, and may increase mortality, in patients with systolic heart failure and a QRS duration of less than 130 msec. The study was led from the Clinic for Cardiology at the University Hospital of Zurich (Switzerland), with Dr. Josep Brugada, head of the IDIBAPS team Arrhythmias, Resynchronization and Cardiac Imaging and Medical Director at Hospital Clínic of Barcelona, and Dr. Lluis Mont, from the same team, among its authors. Its results should allow a better use of the resynchronization therapy avoiding its use in patients in whom it is not indicated and even in some cases preventing a possible harm to the patient.
The recent use of advanced proteomic approaches is clearly challenging the understanding of sperm biology. The group led by Dr. Rafael Oliva, within the IDIBAPS Molecular genetics Team, has provided in the recent years a series of original works about the composition and complexity of sperm. With a new review, published recently at Human Reproduction Update with Alexandra Amaral as its firs author, the team discusses various human sperm proteomic studies to create a compiled list of all the sperm proteins described to date and to re-assess the potential functional implications. The group also leads the Reprotrain project, funded by the European Commission.
Treatment of atrial fibrillation through ablation is more effective than antiarrhythmic drug treatment
A recent study, conducted in 8 hospitals in Spain and led from the Hospital Clínic – IDIBAPS, has randomly compared catheter ablation vs. antiarrhythmic drug in the treatment of persistent atrial fibrillation. The SARA Study (Study of Ablation vs Antiarrhythmic Drugs in Persistent Atrial Fibrillation) has been published as Fast Track in the journal European Heart Journal. After one year of monitoring, the study concludes that treatment with ablation is more effective than antiarrhythmic drugs in preventing relapse of the arrhythmia. In the group treated with ablation the 70% of patients did not present any long lasting relapse of the arrhythmia, whereas among patients treated with antiarrhythmic drugs only 43 % were free of relapse during the follow-up. Dr. Lluis Mont, from the Cardiology Department at Hospital Clínic de Barcelona and IDIBAPS investigator at the Arrhythmias, resynchronization and cardiac imaging Team, is the first author of the study, while Dr. Josep Brugada, from the same service and research team and also Medical Director of the Hospital Clínic, is the last one.
A study led by Inherited Metabolic Diseases IDIBAPS team, directed by Dr. Antònia Ribes from Hospital Clínic of Barcelona, identified in one patient the LIPT1 gene as a new element involved in the metabolism of lipoic acid. Thanks to these results, now published in the journal Human Molecular Genetics, Frederic Tort received the first prize for the best oral presentation at the 12th International Congress of Inborn Errors of Metabolism (ICIEM), held in September in Barcelona.