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Monday November 17th, 2014

A monoclonal antibody shows greater efficacy than conventional chemotherapy in patients with advanced melanoma

The prestigious New England Journal of Medicine (NEJM) publishes an article in its latest issue that demonstrates the efficacy of a monoclonal antibody (Nivolumab) in increasing overall survival and response to treatment in patients with metastatic melanoma compared with conventional treatment with chemotherapy (Dacarbazine). Dr. Ana Arance, Senior Specialist of the Medical Oncology Department at Hospital Clínic, is one of the authors of this study, the first to analyze the use of this drug in previously untreated patients with disseminated melanoma. This new article positions the Medical Oncology Department, headed by Dr. Aleix Prat, as an international referent in the study of melanoma.

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Thursday November 13th, 2014

Researchers identify a key protein in pancreatic cancer development

Researchers from the IDIBAPS and the University of Barcelona (UB) have described an interaction between the protein HNRNPA2B1 and pancreatic cancer development which remained unknown. The study, published in the journal Gastroenterology, has proved in human cancer cell lines that this protein is essential to the correct activity of the oncogenic protein KRAS, related to cancer start and development. The interaction between HNRNPA2B1 and the protein codified by the gene KRAS is a potential therapeutic target against pancreatic cancer, one of the tumours with a worse prognosis. The study was conducted by Neus Agell, professor at the Department of Cell Biology, Immunology and Neurosciences of the Faculty of Medicine of UB, who leads the Cellular compartments and signaling team at IDIBAPS. The first author of the study is Carles Barceló, PhD Student at the former UB Department.

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Wednesday November 12th, 2014

A study shows that elite controllers have a similar genetic profile to that of HIV-uninfected people

The elite controllers (EC) are those people in whom AIDS does not progress despite being infected with HIV. A study led by the IDIBAPS and published in the PLOS ONE journal focuses on whether these EC have a specific genetic profile, different from other patients with HIV, which allows them to control viremia without the need of antiretroviral therapy. Thus, researchers have identified 23 miRNAs differentially expressed, four of which are over-expressed in EC and people without the disease and another 19 are under-expressed in this population compared to patients with HIV. The study was led by Dr. Mireia Arnedo and Dr. Montserrat Plana, researchers at the IDIBAPS group of Infectious Diseases and AIDS, led by Dr. Josep Maria Gatell. The article’s first author is Dr. Lander Egaña-Gorroño.

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Tuesday November 11th, 2014

An antiviral combination reaches 97% of effectiveness in liver transplant patients with hepatitis C

In a study published in New England Journal of Medicine (NEJM), a combination of oral antiviral obtained a 97% curation rate for hepatitis C in a group of liver transplant patients in which eradication of infection was only possible in less than 50% of cases until now. Dr. Xavier Forns, Head of Hepatitis Unit at Hospital Clínic and researcher at IDIBAPS and at the Networked Biomedical Research Center in Hepatic and Digestive Diseases (CIBEREHD), leads this study in which his  group is the only European participant.

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Monday November 3rd, 2014

The Hospital Clínic incorporates the first robot which will perform surgical procedures by a single orifice

The Hospital Clinic of Barcelona is from today on the first hospital in Spain, and one of the firsts in Europe in using the new surgical robot da Vinci Xi, a high technology equipment specially able to perform gastrointestinal surgical procedures with the minimal invasion for the patient. Furthermore, in the near future, this new equipment will allow, in a more optimum way, the surgery by a single orifice thanks to the Single Port technology (SP). With this new acquisition the Hospital Clínic has clearly made a strong commitment in the use of robotics for surgical procedures. Dr. Antonio M. de Lacy, Head of the Gastrointestinal Surgery Department, together with Dr. Josep M. Piqué, General Director of Hospital Clínic, Frank van Hyfte, Sales Director at Intuitive Surgical, and Xavier Carbonell, CEO in Palex, have presented this new equipment in a press conference.

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IDIBAPS researchers receive 11 grants from the TV3 Telethon about neurodegenerative diseases

The TV3 Telethon Foundation celebrated yesterday evening a ceremony to present the projects selected to be funded by the 2013 edition dedicated to neurodegenerative diseases. The more than 11 million euro collected in the last edition have been distributed in 44 research projects, which have passed a rigorous evaluation process. Eleven of the chosen projects correspond to researchers from IDIBAPS, and therefore it becomes the institution that coordinates the greater number of projects in this edition. Read the rest of this entry »

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